Getting to this land that was to become Danville needed an access route. The Dick's River was a major branch of the Kentucky River, with head waters near the Wilderness Road from the southeast. Coming down the Ohio would require you to paddle up stream on the Kentucky or the Salt River. [From the north or northwest.] Which way proved the easiest and the safest was open to discussion and your point of origin.
The following figure shows the relationship of the four main water routes into Danville.
Clark's Run seemed the branch of the Dick's River that ran the closest to the heart of Danville. It would most likely be the source of the springs that were so necessary to early settlements. Spear's Creek and Mock's Branch were north of the land that was to become Danville. [Clark's Run in orange, Spear's Creek green, and Mock's Branch in pink.]
The red marker outlines the flow of the Salt River. This was a branch of the Ohio River, just below the falls. It was the major route of those early surveyors that came to this area in 1774. James Harrod and his group would have something to say about the land around these water routes.
Yes sir, north, south, east, and west...which branches are the best.